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    <title>CowTippingIII-rev - Stikked</title>
    <description>CowTippingIII-rev - Stikked</description>
    <atom:link href="http://geopaste.scratchbook.ch/view/rss/8e6f5e3d" rel="self" type="application/rss+xml" />
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    <title>Re: CowTippingIII-rev</title>
    <link>http://geopaste.scratchbook.ch/view/8ed080ce</link>
    <pubDate>Thu, 09 Jun 2016 05:29:48 +0200</pubDate>
    <dc:creator>Trisket</dc:creator>
    <guid isPermaLink="false">http://geopaste.scratchbook.ch/view/8ed080ce</guid>
    <description><![CDATA[_/\_/\_/\_ CowTippingIII _/\_/\_/\_ --Notes-- 1. follow all previous cowtippingII (ctipII) instructions 2. final phase mix of ctipII must not be packaged to maintain integrity for upgrade to ctipIII.&#8230;]]></description>
    <content:encoded><![CDATA[<div class="text" style="font-family:monospace;"><ol><li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">_/\_/\_/\_ CowTippingIII _/\_/\_/\_</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">--Notes--</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">1. follow all previous cowtippingII (ctipII) instructions</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">2. final phase mix of ctipII must not be packaged to maintain integrity for upgrade to ctipIII.</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">3. grapefruit and grapefruit juice decrease CYP3A4 activity, increasing blood concentrations of fentanyl, thus should be avoided. Drugs that induce cytochrome P450 3A4 activity may have the opposite effects.</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">===============================================================================================</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">*receipt can be difficult if environmental conditions are not correct</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">*mil to oz conversion is not necessary but recommended</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">*aluminum hydroxide (Al(OH)3 can be introduced before VI7</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;Pharmacokinetic Parameter (mean±SD) &nbsp; 100 mcg &nbsp; 200 mcg &nbsp; 400 mcg &nbsp; 800 mcg</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;*Based on venous sampling.</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;*Data for Tmax presented as median (range)</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Cmax</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;(ng/mL) &nbsp; &nbsp; 0.25 ± 0.14 &nbsp; 0.40 ± 0.18 &nbsp; 0.97 ± 0.53 &nbsp; 1.59 ± 0.90</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;Tmax, minute** (range) &nbsp;45.0</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(25.0 to 181.0) &nbsp; 40.0</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(20.0 to 180.0) &nbsp; 35.0</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(20.0 to 180.0) &nbsp; 40.0</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(25.0 to 180.0)</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;AUC0-inf</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(ng•hr/mL) &nbsp; 0.98 ± 0.37 &nbsp; 2.11 ± 1.13 &nbsp; 4.72 ± 1.95 &nbsp; 9.05 ± 3.72</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;AUC0-tmax (ng•hr/mL) &nbsp; 0.09 ± 0.06 &nbsp; 0.13 ± 0.09 &nbsp; 0.34 ± 0.23 &nbsp; 0.52 ± 0.38</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;T1/2, hr** &nbsp; 2.63</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(1.47 to 13.57) &nbsp; 4.43</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(1.85 to 20.76) &nbsp; 11.09</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(4.63 to 20.59) &nbsp; 11.70</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">(4.63 to 28.63</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">~~ Check mixture ~~ &nbsp;Smegma should be floating, if not PM me with detailed situation</div></li>
<li style="font-weight: normal; vertical-align:top;"><div style="font: normal normal 1em/1.2em monospace; margin:0; padding:0; background:none; vertical-align:top;">&nbsp;</div></li>
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