1. _/\_/\_/\_ CowTippingIII _/\_/\_/\_
2.  
3. --Notes--
4. 1. follow all previous cowtippingII (ctipII) instructions
5. 2. final phase mix of ctipII must not be packaged to maintain integrity for upgrade to ctipIII.
6. 3. grapefruit and grapefruit juice decrease CYP3A4 activity, increasing blood concentrations of fentanyl, thus should be avoided. Drugs that induce cytochrome P450 3A4 activity may have the opposite effects.
7. ===============================================================================================
8. *receipt can be difficult if environmental conditions are not correct
9. *mil to oz conversion is not necessary but recommended
10. *aluminum hydroxide (Al(OH)3 can be introduced before VI7
11.  
12.  Pharmacokinetic Parameter (mean±SD)   100 mcg   200 mcg   400 mcg   800 mcg
13.  *Based on venous sampling.
14.  *Data for Tmax presented as median (range)
15.                          Cmax
16.                        (ng/mL)     0.25 ± 0.14   0.40 ± 0.18   0.97 ± 0.53   1.59 ± 0.90
17.  Tmax, minute** (range)  45.0
18. (25.0 to 181.0)   40.0
19. (20.0 to 180.0)   35.0
20. (20.0 to 180.0)   40.0
21. (25.0 to 180.0)
22.  AUC0-inf
23. (ng•hr/mL)   0.98 ± 0.37   2.11 ± 1.13   4.72 ± 1.95   9.05 ± 3.72
24.  AUC0-tmax (ng•hr/mL)   0.09 ± 0.06   0.13 ± 0.09   0.34 ± 0.23   0.52 ± 0.38
25.  T1/2, hr**   2.63
26. (1.47 to 13.57)   4.43
27. (1.85 to 20.76)   11.09
28. (4.63 to 20.59)   11.70
29. (4.63 to 28.63
30.  
31. ~~ Check mixture ~~  Smegma should be floating, if not PM me with detailed situation
32.