1. --CYP3A4 activity---
2. ctipII should acknowledge the high volume of (KAl(SO4)2·12H2O(s)) given the base and (KOH)specified. Please also note (for idiots) to use a hood when (H2SO4) is added.
3.  
4. _/\_/\_/\_ CowTippingIII _/\_/\_/\_
5.  
6. --Notes--
7. 1. follow all previous cowtippingII (ctipII) instructions
8. 2. final phase mix of ctipII must not be packaged to maintain integrity for upgrade to ctipIII.
9. 3. grapefruit and grapefruit juice decrease CYP3A4 activity, increasing blood concentrations of fentanyl, thus should be avoided. Drugs that induce cytochrome P450 3A4 activity may have the opposite effects.
10. ===============================================================================================
11. *receipt can be difficult if environmental conditions are not correct
12. *mil to oz conversion is not necessary but recommended
13. *aluminum hydroxide (Al(OH)3 can be introduced before VI7
14.  
15.  Pharmacokinetic Parameter (mean±SD)   100 mcg   200 mcg   400 mcg   800 mcg
16.  *Based on venous sampling.
17.  *Data for Tmax presented as median (range)
18.                          Cmax
19.                        (ng/mL)     0.25 ± 0.14   0.40 ± 0.18   0.97 ± 0.53   1.59 ± 0.90
20.  Tmax, minute** (range)  45.0
21. (25.0 to 181.0)   40.0
22. (20.0 to 180.0)   35.0
23. (20.0 to 180.0)   40.0
24. (25.0 to 180.0)
25.  AUC0-inf
26. (ng•hr/mL)   0.98 ± 0.37   2.11 ± 1.13   4.72 ± 1.95   9.05 ± 3.72
27.  AUC0-tmax (ng•hr/mL)   0.09 ± 0.06   0.13 ± 0.09   0.34 ± 0.23   0.52 ± 0.38
28.  T1/2, hr**   2.63
29. (1.47 to 13.57)   4.43
30. (1.85 to 20.76)   11.09
31. (4.63 to 20.59)   11.70
32. (4.63 to 28.63
33.  
34. ~~ Check mixture ~~  Smegma should be floating, if not PM me with detailed situation
35.